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Robert L Sah Selected Research

TIR-199

1/2022Syrbactin-class dual constitutive- and immuno-proteasome inhibitor TIR-199 impedes myeloma-mediated bone degeneration in vivo.

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Robert L Sah Research Topics

Disease

6Osteoarthritis
08/2021 - 04/2008
5Neoplasms (Cancer)
01/2022 - 10/2016
3Neoplasm Metastasis (Metastasis)
10/2020 - 10/2016
3Breast Neoplasms (Breast Cancer)
10/2020 - 07/2019
3Pain (Aches)
04/2019 - 10/2016
3Rheumatoid Arthritis
05/2015 - 01/2012
3Arthritis (Polyarthritis)
05/2015 - 03/2012
3AIDS-Related Complex (ARC)
11/2008 - 01/2003
2Triple Negative Breast Neoplasms
01/2022 - 12/2019
2Multiple Myeloma
01/2022 - 12/2019
2Radiculopathy (Radiculopathy, Cervical)
04/2019 - 01/2018
2Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2018 - 01/2018
2Intervertebral Disc Degeneration
01/2018 - 07/2014
2Osteoporosis
01/2017 - 12/2014
2Hypophosphatasia
08/2012 - 08/2011
2Osteomalacia
08/2012 - 08/2011
2Rickets (Rachitis)
08/2012 - 08/2011
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2022
1Hemorrhage
08/2021
1Hyperalgesia
01/2018
1Hyperglycemia
01/2018
1Disease Progression
01/2018
1Prostatic Neoplasms (Prostate Cancer)
10/2016
1Postmenopausal Osteoporosis
12/2014
1Cardiovascular Diseases (Cardiovascular Disease)
12/2014
1Seizures (Absence Seizure)
08/2012
1Intra-Articular Fractures
05/2012
1Tibial Plateau Fractures
05/2012
1Congenital Abnormalities (Deformity)
08/2011
1Body Weight (Weight, Body)
08/2011
1Stress Fractures (Stress Fracture)
07/2010
1Bone Resorption
03/2009
1Necrosis
04/2008
1Pathologic Processes
01/2008

Drug/Important Bio-Agent (IBA)

3LubricantsIBA
08/2021 - 01/2012
3Proteins (Proteins, Gene)FDA Link
10/2020 - 05/2015
3AlginatesIBA
11/2008 - 01/2003
2CollagenIBA
10/2020 - 01/2004
2BAY 58-2667IBA
01/2018 - 12/2014
2Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA
01/2018 - 12/2014
2Estrogens (Estrogen)FDA Link
01/2017 - 12/2014
2Hyaluronic Acid (Hyaluronan)IBA
01/2016 - 05/2012
2N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA
08/2012 - 08/2011
2EnzymesIBA
08/2012 - 08/2011
2Alkaline PhosphataseIBA
08/2012 - 08/2011
1Proteasome Endopeptidase Complex (Proteasome)IBA
01/2022
1TIR-199IBA
01/2022
1dimemorfan (AT 17)IBA
08/2021
1Pharmaceutical PreparationsIBA
12/2019
1Proteasome InhibitorsIBA
12/2019
1Bortezomib (Velcade)FDA Link
12/2019
1ATP dependent 26S protease (26S proteasome)IBA
12/2019
1Sialyl Lewis X AntigenIBA
07/2019
1OsteoprotegerinIBA
07/2019
1Cytosine DeaminaseIBA
07/2019
1Messenger RNA (mRNA)IBA
07/2019
1P-selectin ligand proteinIBA
07/2019
1Insulin (Novolin)FDA Link
01/2018
1Streptozocin (Streptozotocin)FDA Link
01/2018
1NitratesIBA
01/2017
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2017
1cobinamideIBA
01/2017
1Proteoglycans (Proteoglycan)IBA
05/2015
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
05/2015
1Anabolic AgentsIBA
12/2014
1Guanylate Cyclase (Guanylyl Cyclase)IBA
12/2014
1Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2014
1Soluble Guanylyl CyclaseIBA
12/2014
1VitaminsIBA
08/2012
1Biological FactorsIBA
05/2012
1p38 Mitogen-Activated Protein KinasesIBA
03/2012
1Phosphotransferases (Kinase)IBA
03/2012
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
03/2012
1CytokinesIBA
01/2012
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2012
1salicylhydroxamic acid (SHAM)IBA
08/2011
1asfotase alfaIBA
08/2011
1Collagen Type I (Type I Collagen)IBA
03/2009
1benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA
04/2008
1GlycosaminoglycansIBA
04/2008
1Biological ProductsIBA
01/2008

Therapy/Procedure

4Therapeutics
01/2018 - 12/2014
3Punctures
04/2019 - 07/2014
2Injections
08/2021 - 01/2018
1Heterologous Transplantation (Xenotransplantation)
01/2018
1Glycemic Control
01/2018
1Knee Replacement Arthroplasty (Total Knee Replacement)
01/2017
1Replacement Arthroplasty
05/2012
1Autologous Transplantation
07/2010
1Bone Plates (Bone Plate)
12/2008